SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome

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Hutchinson-Gilford progeria syndrome Left Side Cover is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains.Here, the authors present the SAMMY-seq, a Bike Units - Dual Sport method for genome-wide characterization of heterochromatin dynamics and detect early stage alterations of heterochromatin structure in progeria primary fibroblasts, accompained by Polycomb dysfunctions.